Which of the following is the most common side effect of tissue plasminogen activator (tpa)?5/13/2023 Specific rtPAs include alteplase, reteplase, and tenecteplase. TPA can be manufactured using recombinant biotechnology techniques tPA produced by such means are referred to as recombinant tissue plasminogen activator ( rtPA). Human tPA has a molecular weight of ~70 kDa in the single-chain form. As an enzyme, it catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown. It is a serine protease ( EC 3.4.21.68) found on endothelial cells, the cells that line the blood vessels. Tissue plasminogen activator (abbreviated tPA or PLAT) is a protein involved in the breakdown of blood clots.
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